A mystery surrounds a small town that was attacked on September 9, 2009. Now sixty years later, the last survivor, Sarah, sends a high profile reporter a letter suggesting what really happened on that day. The government calls 9/9/09 the start of the "Modern Plague", and the reporter soon realizes that the truth may be harder to uncover than the lies.

In exchange for his freedom, charming con artist Neal Caffrey provides his expertise to help straight-man FBI agent Peter Burke catch elusive white-collar criminals.

A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.