Griffin Conner, a med-school dropout having left in a haze of disgrace, is forced to return to Bethune General Hospital as its newest orderly and work alongside his family.

Brash and gutsy stripper Bettina and mousy secretary Jeannie are framed for a murder they didn't commit. The radically contrasting distaff duo go on the lam in a red convertible with a half million dollars in cash in a briefcase. Various folks on both sides of the law give hot pursuit.

It is 1957. J.C. Cullen is a young man from a small town, with a talent for winning at craps, who leaves for the big city to work as a professional gambler. While there, he breaks the bank at a private craps game at the Gem Club, owned by George Cole, and falls in love with two women, one of them Cole's wife.