The Grand Hotel formula that was so overworked in the 1930s made an encore appearance in 1940's Escape to Glory. The story is given timeliness by placing the characters on a British merchant ship on the very day that World War II is declared. The ship is attacked by a Nazi U-Boat, resulting in a variety of reactions from the diverse passengers--one of whom (Erwin Kalser) is a German doctor. Constance Bennett is glamorous, Pat O'Brien is boozy, John Halliday is pensive, and everybody else (except for the German medico) is plain fearful.

A mobster's moll leads a newsman, cub reporter and photographer to a scoop.

A southern aristocrat clashes with a driver transporting stolen slaves to freedom.

Harvey, the arrogant and spoiled son of an indulgent absentee-father, falls overboard from a transatlantic steamship and is rescued by a fishing vessel on the Grand Banks. Harvey fails to persuade them to take him ashore, nor convince the crew of his wealth. The captain offers him a low-paid job, until they return to port, as part of the crew that turns him into a mature, considerate young man.

In an effort to be able to afford expensive treatment for her gravely ill American husband, a retired German entertainer returns to the cabaret as Blonde Venus and catches the eye of a wealthy politician.