Twenty-four-year-old Kara Zor-El, who was taken in by the Danvers family when she was 13 after being sent away from Krypton, must learn to embrace her powers after previously hiding them. The Danvers teach her to be careful with her powers, until she has to reveal them during an unexpected disaster, setting her on her journey of heroism.

Elegant, proper Grace and freewheeling, eccentric Frankie are a pair of frenemies whose lives are turned upside down - and permanently intertwined - when their husbands leave them for each other. Together, they must face starting over in their 70s in a 21st century world.

Young Bobby Spade who has an anxiety disorder, discovers that his therapy dog Ozzy is actually 600 years old and was once owned by a powerful wizard from ancient times. Upon his twelfth birthday, Bobby is propelled into a new life when he learns the truth about his faithful pet who soon determines the boy and his widowed mother's destiny.

Follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital.