The Devil's daughter rises from the grave, bringing with her zombies, werewolves, vampires and the armies of Hell to destroy Earth. Mankind's only hope for salvation lies in a young hippie girl and a comic book geek.

The film is a triptych of more or less connected vignettes, two of which are suggested by a song with the same name of the title by the Spanish singer Alaska. It has elements of black humor, gore, grindhouse among other things.