In New York City, bright but naive New Englander Anne Welles becomes a secretary at a theatrical law firm, where she falls in love with attorney Lyon Burke. Anne befriends up-and-coming singer Neely O'Hara, whose dynamic talent threatens aging star Helen Lawson and beautiful but talentless actress Jennifer North. The women experience success and failure in love and work, leading to heartbreak, addiction and tragedy.

A San Francisco private eye finds himself under suspicion while investigating a prizefighter's murder.

The Bumstead family is off to see relatives in the country when Blondie runs into Charlie and Millie, an eloping couple needing her help.

Betty Bryant is an ambitious newspaper reporter in love with Dan Barton, a member of a big-city Emergency Squad who are trained to deal with riots, cave-in, explosions, fires and other emergencies where lives are at stake. Slade Wiley, an unscrupulous tunnel builder, finds that his low bid on the Newford Tunnel project is causing him to lose a lot of money, and has underworld leader Nick Burton set off blasts to frighten the stockholders into selling their shares at a low price so he can buy up the stock. Betty is investigating the deal when Wiley and Burton take her on a "tour trip" to the tunnel.

A mobster's moll leads a newsman, cub reporter and photographer to a scoop.

An ad man gets his model girlfriend to pose as a debutante for a new campaign.

J.B. Ball, a rich financier, gets fed up with his free-spending family. He takes his wife's just-bought (very expensive) sable coat and throws it out the window, it lands on poor hard-working girl Mary Smith. But it isn't so easy to just give away something so valuable, as he soon learns.

The small-town prudes of Lynnfield are up in arms over 'The Sinner,' a sexy best-seller. They little suspect that author 'Caroline Adams' is really Theodora Lynn, scion of the town's leading family. Michael Grant, devil-may-care book jacket illustrator, penetrates Theodora's incognito and sets out to 'free her' from Lynnfield against her will. But Michael has a secret too, and gets a taste of his own medicine.

Charlie Mason and Rusty Fleming are star reporters on a Chicago tabloid who are romantically involved as well. Although skilled in ferreting out great stories, they often behave in an unprofessional and immature manner. After their shenanigans cause their frustrated city editor to resign, the publisher promotes Charlie to the job, a decision based on the premise that only a slacker would be able crack down on other shirkers and underachievers. His pomposity soon alienates most of his co-workers and causes Rusty to move to New York. Charlie resigns and along with gangster friend Smiles Benson tries to win Rusty back before she marries a stuffy society author.

Sassy manicurist Eve Fallon is recruited as an even more brassy reporter and she helps police detective boyfriend Danny Barr break a jewel theft ring and solve the murder of a baby.

A crusading young reporter planning a series of articles about a corrupt politician is framed for a crime and sentenced to serve five years at a prison farm.