Set in downtown New York in 1900, 'The Knick' is centered on the Knickerbocker Hospital and its staff, notably Dr. John Thackery, the hospital's brilliant chief surgeon who pushes medicine's boundaries, pioneering new procedures despite a severe drug addiction.

A year after his father's death, Oskar, a troubled young boy, discovers a mysterious key he believes was left for him by his father and embarks on a scavenger hunt to find the matching lock.

Greg Focker is ready to marry his girlfriend, Pam, but before he pops the question, he must win over her formidable father, humorless former CIA agent Jack Byrnes, at the wedding of Pam's sister. As Greg bends over backward to make a good impression, his visit to the Byrnes home turns into a hilarious series of disasters, and everything that can go wrong does, all under Jack's critical, hawklike gaze.

A Puerto-Rican ex-con, just released from prison, pledges to stay away from drugs and violence despite the pressure around him, and lead a better life outside NYC.