Charlie and Mitch arrive at Charlie’s mother’s home to come out of the closet as stoners. But Charlie's fear of being exiled drags out the process—until somebody is caught with their pants down.

Five college pals head out of town for a fun weekend, but plans quickly change after they encounter a strange 7-year old girl at an abandoned roadside cafe and offer to drive her home - and come face to face with evil incarnate.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.