Columbia Pictures elevated a run-of-the-mill B-western supporting player, Marshall Reed, to the title role in this equally run-of-the-mill western serial released in 15 chapters. Like most serials in the '50s, Riding with Buffalo Bill consisted of quite a bit of budget-stretching stock footage telling a highly fictionalized account of Buffalo Bill Cody aiding a group of ranchers in their defeat of a local crime lord. The serial's assistant director, Leonard Katzman, later produced the long-running television series Gunsmoke and Dallas.

A movie star helps a young singer-actress find fame, even as age and alcoholism send his own career into a downward spiral.

Reformed parolee Steve Lacey is caught in the middle when a wounded former cellmate seeks him out for shelter. The other two former cellmates then attempt to force him into doing a bank job.

A New York sculptor who opens a wax museum to showcase the likenesses of famous historical figures runs into trouble with his business partner, who demands that the exhibits become more extreme in order to increase profits.

A daffy door-to-door saleswoman blunders into a murder investigation.