The Hitter, the Hacker, the Grifter and the Thief are together again, this time with help from a new tech genius and corporate fixer, to take on a new kind of villain. From the man who created an opioid crisis from the comfort of his boardroom to the shadowy security firm that helps hide dangerous secrets for a price - when someone needs help, they provide... Leverage.

Even though Sami is safe in the United States with his 9-year-old daughter, Aya, the injures sustained during the war in Syria are making his life difficult. When news breaks that the rest of his family will arrive from a refugee camp, he should be as elated as Aya. But as Aya grows more eager to see her brother Saeed, Sami grows more anxious.

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A vast international plot explodes when a beautiful Jane Doe is discovered naked in Times Square, completely covered in mysterious, intricate tattoos with no memory of who she is or how she got there. But there's one tattoo that is impossible to miss: the name of FBI agent Kurt Weller, emblazoned across her back. "Jane," Agent Weller and the rest of the FBI quickly realize that each mark on her body is a crime to solve, leading them closer to the truth about her identity and the mysteries to be revealed.

Sam, a soldier who had served in Afghanistan and Iraq, meets Amira when he visits her uncle, Bassam, who had served as Sam's Iraqi translator. Bassam and Sam have a special bond due to their time together in the war. Initially Amira does not trust him because he was an American soldier and her brother was killed by a bomb from American troops in the war. Sam's cousin, Charlie, asks Sam to help him with illegal hedge funds unbeknownst to Sam at the time. Amira is staying with her uncle Bassam since her father died. She sells bootlegged films on the street corner but is forced to stay with Sam after getting busted; immigration officials begin pursuing her. As the film progresses, Sam and Amira fall in love.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.