Once upon a time in Little Italy, a mob widow plots to avenge the death of her husband with the help of the local gypsies. Her vendetta involves supernatural machinations which help to control the fates and destinies of members of the four prominent mafia families: the Moronis, Mancinis, Mascolos, and Assissis.

A brother and sister reunite following a five-year hiatus and are forced to stumble towards reconciliation.