A quartet of stories unfold across four holidays as family members, friends and colleagues face hard decisions, career setbacks and life-changing events.

Day zero: When it all begins, in a funeral home. Day #1466: When the epidemic has already devoured the entire planet, set in a house in the woods. Day #2333: When the zombies have become something more than the monsters that we know, in a prison surrounded by post-apocalyptic scenarios.

Reports of a weeping Madonna in Italy reach Las Vegas, where blackjack dealer Maggie has just learnt she has only weeks to live. With a massive leap of faith she convinces herself that seeing the Madonna with her own eyes could lead to her salvation, and travels to Europe to find it. Hitching through Italy, she meets pianist Mike, who is also en route to what he believes could be a life-changing event - a performance at the Barbarina concert in Naples.