Dr. Frankenstein and his monster both turn out to be alive, not killed as previously believed. Dr. Frankenstein wants to get out of the evil experiment business, but when a mad scientist, Dr. Pretorius, kidnaps his wife, Dr. Frankenstein agrees to help him create a new creature.

Working in Dr. Cranley's laboratory, scientist Jack Griffin was always given the latitude to conduct some of his own experiments. His sudden departure, however, has Cranley's daughter Flora worried about him. Griffin has taken a room at the nearby Lion's Head Inn, hoping to reverse an experiment he conducted on himself that made him invisible. But the experimental drug has also warped his mind, making him aggressive and dangerous. He's prepared to do whatever it takes to restore his appearance.

Tampering with life and death, Henry Frankenstein pieces together salvaged body parts to bring a human monster to life; the mad scientist's dreams are shattered by his creation's violent rage as the monster awakens to a world in which he is unwelcome.