Lone-wolf detective Angie Tribeca and a squad of committed LAPD detectives investigate the most serious cases, from the murder of a ventriloquist to a rash of baker suicides.

An ordinary suburbanite couple discovers that the natural world simply vanished during the night. Yet even stranger, all of their neighbors carry on with their daily routines.

A fresh and funny take on modern friendship and what one urban family will do to stay friends after the perfect couple who brought them all together break up on their wedding day. The failed wedding forces them all to question their life choices. Then there are Alex and Dave themselves, who strike a truce and must learn to live with the changes their breakup has brought.

Thanks to a Japanese scientist's invention of synthetic, blood vampires have progressed from legendary monsters to fellow citizens overnight. And while humans have been safely removed from the menu, many remain apprehensive about these creatures "coming out of the coffin." Religious leaders, government officials, and vampire fundamentalists around the world have chosen their sides, but in the small Louisiana town of Bon Temps, the jury is still out.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.