The title represents the hopeful, ambitious students at a hospital training school and is primarily a story of the stern discipline and laborious physical and mental toil they endure in order to become nurses and join the White Parade. It is told mainly through the character of June Arden who finds romance with Ronald Hall III on the way, with side stories of the other girls who find failure, success, laughs and tears on the way.

A young couple struggling against poverty must keep their marriage a secret in order for the husband to keep his job, as his boss doesn't like to hire married men.

Young Parisian Nana wards off of a boozed-up military officer at a local restaurant, and fellow diner Gaston Greiner is so impressed with her pluck that he decides to make her a performer at his musical theater. Soon, Nana is a star, and the girlfriend of Greiner and two other men. But when he learns that she's been getting around, Greiner fires her. As she tries to reclaim her singing job while dodging yet another suitor, her treachery might get the better of her.

In Kentucky just after the Civil War, the Hayden-Colby feud leads to Jed Colby being sent to prison for 15 years for murder. The Haydens head for Nevada and when Colby gets out of prison he heads there also seeking revenge. The head of the Hayden family tries to avoid more killing but the inevitable showdown has to occur, complicated by Lynn Hayden and Ellen Colby's plans to marry.

According to a legend, the mansion's "blue room" is cursed -- everyone who has ever spent the night in that room has met with an untimely end. The three suitors of the heroine wager that each can survive a night in the forbidding blue room.

Ruby falls in love with small-time con man Eddie. During a botched blackmail scheme, Eddie accidentally kills the man they were setting up. Eddie takes off and Ruby is sent to a reformatory for two years.

Cynthia Warren, independently wealthy through her ability as an illustrator and poster artist, rebels against the premise that every woman is destined for matrimony and motherhood and decides she has as much right as a man to play around.

Gunner and Bucker are friends who work as riveters. Whenever Bucker gets the urge to marry, which is often, Gunner will hit on his girl to see if she is true or not. So far, Gunner hasn't failed. But one night, while Gunner is in jail, Bucker meets Mary, a tough dame with a line. He falls for her, and she falls for his money. But Mary is already a gal pal of Gunner, and no two know about the third one. The trouble starts when the triangle is revealed too late.