Cree matriarch Aline Spears survives a childhood in Canada’s residential school system to continue her family’s generational fight in the face of systemic starvation, racism, and sexual abuse. She uses her uncanny ability to understand and translate codes into working for a special division of the Canadian Air Force as a Cree code talker in World War II. The story unfolds over 100 years with a cumulative force that propels us into the future.

Despite their opposing personalities, a talented but directionless P.I. who is the black sheep of his family begrudgingly agrees to work as the in-house investigator for his overbearing mother, a successful attorney reeling from the recent dissolution of her marriage.

In 2033, people who are near death can be “uploaded” into virtual reality hotels run by 6 tech firms. Cash-strapped Nora lives in Brooklyn and works customer service for the luxurious “Lakeview” digital afterlife. When L.A. party-boy/coder Nathan’s self-driving car crashes, his high-maintenance girlfriend uploads him permanently into Nora’s VR world.

Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

The Desmond - the building's pleasant sounding name hides a troubled past. The high rise has a long history of fires, murders, madness and even colonial era genocide upon the site. The towering building has stood empty for the better part of a century and even squatters dare not enter it's fortress like walls. But now Johnny Craig, the host of the popular TV paranormal investigation show 'America's Most Haunted' is planning to do a prime-time special from inside The Desmond. With no known way in, or out, Craig has contacted a group of urban explorers to help him and his film crew enter the building. But when Craig and his team set foot inside The Desmond the events that caused the building to be abandoned in the first place begin to repeat.