The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.

Decorated Vietnam hero, Frank Vega returns home only to get shunned by society leaving him without a job or his high school sweetheart. It's not until forty years later when an incident on a commuter bus makes him a local hero where he's suddenly celebrated once again. But his good fortune suddenly turns for the worse when his best friend is murdered and the police aren't doing anything about it.

Having navigated the awkward and sometimes traumatic world of high school, Rebecca Freely returns to her alma mater as a guidance counselor, free of the insecurities and orthodontia of her school days. Amidst student behavioral problems and the persistent romantic advances of the male nurse, Gary, Rebecca is certain of one thing - she is interested in the hot auto-shop-turned-Spanish-teacher, Tim. However, much as in high school days of unexpected teenage angst, Lisa, a former cheerleader and nemesis of Rebecca's, returns as the new English teacher determined to make Rebecca relive her unpopular past, setting sights on Tim as well.

Complex, offbeat Detective Charlie Crews returns to the force after serving time in prison for a crime he didn’t commit. Crews’ new lease on life has provided him with a Zen-like outlook, peace of mind and no need for vengeance, an attitude which can be challenging to maintain when someone he cares about is threatened — or when he is investigating the mystery surrounding the murder he was falsely accused of.

Danny Ocean's team of criminals are back and composing a plan more personal than ever. When ruthless casino owner Willy Bank doublecrosses Reuben Tishkoff, causing a heart attack, Danny Ocean vows that he and his team will do anything to bring down Willy Bank along with everything he's got. Even if it means asking for help from an enemy.

Meet the Diffy family, a futuristic family from the year 2121. When the eccentric dad, Lloyd, rents a time machine for their family vacation, everyone is excited. But then something goes wrong. Their time machine malfunctions and they are thrown out of the space/time continuum in the year 2004.