In Renaissance Florence, a Florentine trader meets a shipwrecked stranger, who introduces himself as Tito Melema, a young Italianate-Greek scholar. Tito becomes acquainted with several other Florentines, including Nello the barber and a young girl named Tessa. He is also introduced to a blind scholar named Bardo de' Bardi, and his daughter Romola. As Tito becomes settled in Florence, assisting Bardo with classical studies, he falls in love with Romola.

La tempesta in un cranio (Tempest in a Cranium) is an anarchic, quasi-surreal Italian comedy of multiple delights in which the timorous scion of a wealthy family is gaslit by his friends in order to prove that his fears of hereditary insanity are hogwash.