Franklin Roosevelt, left a paraplegic from polio at 39 years of age, seeks out a miracle cure in the backwoods of Georgia.

A man asks his wife for a 'leave of absence' in order to care for his mistress who is dying of cancer.

A rich man's mistress gets in the middle of a high-society murder in Beverly Hills.

Marguerite Sydney is a celebrated Hollywood star attempting a comeback after a stay in a mental hospital, as well as trying to re-establish a relationship with her teenage son, and risking a romance with a mysterious stranger.

A cross-country road race is based on an actual event, the Cannonball Baker Sea to Shining Sea Memorial Trophy Dash, organized by Brock Yates to protest the 55 mph speed limit then in effect in the U.S. The Cannonball was named for Erwin G. "Cannonball" Baker, who in the roaring 20's rode his motorcycle across the country. Many of the characters are based on ruses developed by real Cannonball racers over the several years that the event was run.

Madie is a neurotic, wealthy woman who escapes from a New York state mental hospital where her unwholesome husband had her committed to avoid the trial of a expensive divorce. Madie hitches a ride back to California with a certain Charles Callahan, a debt-ridden truck driver. Madie and Charles eventually fall in love while evading an assortment of bad guys including a pair of thugs hired by Madie's husband to prevent her from returning to California, and a repo man sent to reclaim Charles' truck

Dennis Weaver is a Joseph Wambaugh-type novelist cop and Pat Hingle is his hard-nosed superior who wants him to stick to police work or get off the force in this pilot to the short-lived series.