An Australian nurse discovers an effective new treatment for infantile paralysis, but experiences great difficulty in convincing doctors of the validity of her claims.

The election to determine if Texas will become a state is near and men opposed are running contraband across the border. Sunset and Frog are Border Patrolmen and have an agent that tips them off by carrier pigeon. The Army arrives and the commander is Sunset's brother. When the agent is found out and murdered, his fake replacement then leads the soldiers astray.

Railroad agents frame a landowner who wont sell out to them.

When Edward Creighton leads the construction of the Western Union to unite East with West, he hires a Western reformed outlaw and a tenderfoot Eastern surveyor.

Frank Sr. sells his supplies to Hook, but then Hook has the Bannion Boys bushwhack his wagon to get the money back. Frank is murdered, but Junior gets away. He comes back 10 years later to settle the score as the Singing Cowboy. He finds that Hook is still doing his dirty deeds on the unsuspecting people. Along the way, Frank meets the lovely Jen, who came out in the same wagon train 10 years before.