When 4 year old Amanda McCready disappears from her home and the police make little headway in solving the case, the girl's aunt, Beatrice McCready hires two private detectives, Patrick Kenzie and Angie Gennaro. The detectives freely admit that they have little experience with this type of case, but the family wants them for two reasons—they're not cops and they know the tough neighborhood in which they all live.

The year is 2021 AD. Women have been enslaved by a brutal army of men who survived the nuclear holocaust. Their only hope for freedom is in the hands of a nomadic band of fierce she-warriors: The Sisterhood.