The story of two teenage girls who discover they were accidentally switched as newborns in the hospital. Bay Kennish grew up in a wealthy family with two parents and a brother, while Daphne Vasquez, who lost her hearing at an early age due to a case of meningitis, grew up with a single mother in a working-class neighborhood. Things come to a dramatic head when both families meet and struggle to learn how to live together for the sake of the girls.

When this year's round of unsuspecting Northerners fail to show up for their annual Guts N' Glory Jamboree, the residents of Pleasant Valley take their cannibalistic carnival on the road and head to Iowa where they encounter spoiled heiresses Rome & Tina Sheraton and the cast and crew of their "Road Rascals" reality show. Performing "The Bloodiest Show on Earth", our Southern Maniacs prove more than ratings killers in what John Landis has called "one of the rare sequels that surpasses the original".