Leo, a holocaust survivor who suffers from total amnesia, comes to the U.S. and works as a hotel desk clerk. One night while a comedian who owns a bar in the hotel gives him a drink, he breaks out in song and discovers a great voice. Under a psychiatrist's treatment, and because of a blow to the head by some hoodlums, he realizes his name is David and that he was the son of a great Jewish Cantor, and gradually recovers his memory of losing his parents. He gives up a promising career singing in nightclubs to return to the synagogue.

The Ed Sullivan Show is an American TV variety show that originally ran on CBS from Sunday June 20, 1948 to Sunday June 6, 1971, and was hosted by New York entertainment columnist Ed Sullivan. It was replaced in September 1971 by the CBS Sunday Night Movie, which ran only one season and was eventually replaced by other shows. In 2002, The Ed Sullivan Show was ranked #15 on TV Guide's 50 Greatest TV Shows of All Time.

A humble cantor, Oysher yearns to be an opera singer. He deserts his tiny village to pursue his dream, but when his voice breaks he sheepishly returns, resigned to attending but not singing at the Yom Kippur services. Upon his return, Oysher is informed that his son has died. Out of grief is wrought a miracle: Oysher's voice returns, more powerful than ever. After performing the Day of Atonement services, Oysher suddenly collapses, peacefully joining his son in death. If you wish to see the touching Overture to Glory, by all means seek out a decent print; many extant copies are so washed out that, not only are the English subtitles unreadable, but it's extremely difficult to tell one actor from another.

This musical drama marks the screen debut of Moishe Oysher, in a film critic J. Hoberman calls an "anti-Jazz Singer." Oysher stars as a wayward youth who makes his way from his Polish shtetl to New York's Lower East Side where he is "discovered" and becomes a well-known singer. Ultimately, he returns home to the Old Country and reunites with his parents and his childhood sweetheart.