As a young associate, Mitchell McDeere brought down the prestigious Memphis law firm of Bendini, Lambert & Locke, which operated as a front for the Chicago mob—and his life was never the same. After a difficult decade, which included a stay in the Federal Witness Protection program, Mitch and his family now emerge from isolation to reclaim their lives and their future—only to find that past dangers are still lurking and new threats are everywhere.

Sydney Fox is a professor and globe-trotting "relic hunter" who looks for ancient artifacts to return to museums and/or the descendants of the original owner. She is aided by her linguistic assistant Nigel and occasionally by her somewhat air-headed secretary Claudia. She often ends up battling rival hunters seeking out artifacts for the money.

A secretary is found dead in a White House bathroom during an international crisis, and Detective Harlan Regis is in charge of the investigation. Despite resistance from the Secret Service, Regis partners with agent Nina Chance. As political tensions rise, they learn that the crime could be part of an elaborate cover-up. Framed as traitors, the pair, plus Regis' partner, break into the White House in order to expose the true culprit.