The young priest Father Giulio returns to Rome, his hometown, after a long pilgrimage. Don Giulio hopes to live peacefully with his family and his friends, but discovers that many of them are depressed or frustrated, and some suicidal.

Eccentric and full of manias, Michele is a young high school professor who defines himself as “not used to happiness”. He realizes his life is meaningless if he doesn’t have a woman by his side but, after a series of rather disastrous experiences, he feels more alone than ever. Then, out of the blue, a new French teacher called Bianca arrives at school. Amongst uncertainties and contradictions, the two start dating. In the meantime, a series of homicides take place and a police officer begins to suspect that Michele is involved. Bianca will save him providing an alibi at the right moment, but then, everything goes wrong again.