When Lupe is 22 years old, her life suddenly changes after she learns that her father, a famous Colombian singer-songwriter, has died. Upon arriving in Colombia, Lupe meets Noah, a mysterious character who turns out to be her father's assistant. Instead of returning to Mexico, Lupe decides to stay as she suspects that the musician's death was not an accident. Together with Noah, she will embark on a musical adventure full of danger, mystery and romance, in the Caribbean region of Colombia.

Daisy O'Brian is a normal girl who dreams of a singing career in musical comedy. Her parents are vampires, and per her family tradition, she must decide to become a vampire or not on her 16th birthday. On that day, Daisy decides to stay human to live next to her love, Max, who is her neighbor and classmate. However, that same day, a fatal accident changes her life forever. The doctor says to her parents that she is not going to make it. So, her parents decide to bite Daisy, to save her, turning her into a vampire. This makes Vicente (her younger brother) the only mortal in the family. From that moment, Daisy leads a double life full of risks, where she must attend a human school, hiding her nature, and also go to vampire school and take classes for newly bitten vampires.

Petra and Matthias are a bad marriage. He works as a janitor at the school of anatomy. Petra has a bitter and uncompromising character, so that their discussions with Matthias are constant, but she is careful not to ever lift his voice. He, however, does not care who tell and shouts without hesitation. The neighbors, who are some gossips are at the end of the street everything that happens in the house of Petra and Matthias.