Every Tuesday night, radio talk show host Stevie Bricks invites his listeners to call in and share their stories. When one night he asks people to share the worst thing they’ve ever done, high school teacher Ron Welz can't resist. Big mistake—what he reveals sets off a chain of hilariously uncontrollable events adversely affecting his marriage and another couple. And when someone starts sending him body parts, his life really begins to fall apart. Who is tormenting him? An insolent high school student? His best friend? His wife? There are over eight million people in the Naked City, and everyone's a suspect.

Liza Miller, a suddenly single stay-at-home mother, tries to get back into the working world, only to find it’s nearly impossible to start at the bottom at 40-year old. When a chance encounter convinces her she looks younger than she is, Liza tries to pass herself off as 26 and lands a job as an assistant at Empirical Press. Now she just has to make sure no one finds out the secret only she and her best friend Maggie share.