A sex therapist goes through puberty after the successful removal of a benign tumor resting against his pituitary gland. He experiences all the changes and effects of puberty over a three-week period.

Dr. Ken is a brilliant physician with no bedside manner. He is always trying to be a good doctor, as well as a good husband and dad to his two kids. However, these good intentions have a way of driving everyone crazy at both work and at home. Luckily, his therapist wife Allison is just the right partner to keep things sane.

Jessica Day is an offbeat and adorable girl in her late 20s who, after a bad breakup, moves in with three single guys. Goofy, positive, vulnerable and honest to a fault, Jess has faith in people, even when she shouldn't. Although she's dorky and awkward, she's comfortable in her own skin. More prone to friendships with women, she's not used to hanging with the boys—especially at home.

A financially strapped couple makes an emergency cross country trip with an eccentric stranger named Jeffie. Tightly-held secrets are unraveled as Jeffie takes his travel companions on an unpredictable life-changing journey.

The everyday lives of office employees in the Scranton, Pennsylvania branch of the fictional Dunder Mifflin Paper Company.