Warren Nefron is a hopeless klutz who has some of the worst luck in the world: when he tries to end it all with a foolproof suicide plan, he still manages to mess it up. In desperation, he goes to a psychiatrist to see if there is some way for him to end his troubles.

The three single roommates Janet Wood, Chrissy Snow and Jack Tripper all platonically share Apartment 201 in a Santa Monica, California apartment building owned by Mr. and Mrs. Roper.