When Howard Brookner lost his life to AIDS in 1989, the 35-year-old director had completed two feature documentaries and was in post-production on his narrative debut, Bloodhounds of Broadway. Twenty-five years later, his nephew, Aaron, sets out on a quest to find the lost negative of Burroughs: The Movie, his uncle's critically-acclaimed portrait of legendary author William S. Burroughs. When Aaron uncovers Howard's extensive archive in Burroughs’ bunker, it not only revives the film for a new generation, but also opens a vibrant window on New York City’s creative culture from the 1970s and ‘80s, and inspires a wide-ranging exploration of his beloved uncle's legacy.

A portrait of the American Beat Generation writer William S. Burroughs (1914-1997) based on never-before-seen footage from his visit to Denmark in October 1983, and from his later years in Lawrence, Kansas. After having spent more than a quarter of a century outside of the United States, in Mexico, Tangier, Paris and London, Burroughs returned to New York in 1974. Shortly after, he began touring and reading his work to new generations of readers and thus establishing himself as a cult figure. The film focuses on Burroughs' unique talent as a performer, and on his later work, especially what is known as The Last Trilogy. In addition to the historic footage there are new interviews with friends and colleagues.

An exploration of Burroughs’ life story, as told by Burroughs himself along with many of his contemporaries, including Allen Ginsberg, Brion Gysin, Francis Bacon, Herbert Huncke, Patti Smith, Terry Southern, and William Burroughs Jr.