Arrogant, self-centered movie director Guido Contini finds himself struggling to find meaning, purpose, and a script for his latest film endeavor. With only a week left before shooting begins, he desperately searches for answers and inspiration from his wife, his mistress, his muse, and his mother.

Pleasantly plump teenager Tracy Turnblad auditions to be on Baltimore's most popular dance show - The Corny Collins Show - and lands a prime spot. Through her newfound fame, she becomes determined to help her friends and end the racial segregation that has been a staple of the show.

Murderesses Velma Kelly and Roxie Hart find themselves on death row together and fight for the fame that will keep them from the gallows in 1920s Chicago.