Fed up with all the attention going to Bugs Bunny, Daffy Duck quits Hollywood, teams up with recently-fired stuntman Damien Drake Jr. and embarks on a round-the-world adventure, along with Bugs and The VP of Warner Bros. Their mission? Find Damien's father, and the missing blue diamond... and stay one step ahead of The Acme Corp., who wants the diamond for their own purposes.

After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!