David, a struggling comedy writer fresh off from breaking up with his boyfriend, moves from New York City to Sacramento to help his sick mother. Living with his conservative father and much-younger sisters for the first time in ten years, he feels like a stranger in his childhood home. As his mother’s health declines, David frantically tries to extract meaning from this horrible experience and convince everyone (including himself) that he's "doing okay.”

Punk-rocker turned suburban mom, Kelly, is nostalgic for a life she can no longer have and uncertain of a future she doesn’t yet fit in. Seventeen-year-old Cal is frustrated at his lack of control over the hand he's been dealt. When the two strike up an unlikely friendship, it's the perfect spark needed to thrust them both back to life.

When Angelino Jack Robinson gets a new job in Australia, he decides to take his sissy wife Ann, brave sons Shane and Todd and wining daughter Elisabeth 'Lizzy' by sailing yacht from Hong Kong to Syndney. The gun he gets thrown in by Sheldon Blake proves disabled, and for a sinister reason: near Borneo, Blake's men turn up to capture them. The family escapes but loses the yacht on a reef. They build a cool camp on an island. But the pirates keep coming back, and the boys discover why: he hid a treasure in the yacht. Shane is also discovered and captured in more then one way by French plane wreck survivor Françoise, who later teams up with the family.

Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.