Ethan and team take on their most impossible mission yet—eradicating 'The Syndicate', an International and highly-skilled rogue organization committed to destroying the IMF.

London is in lock-down whilst the police search for a terrorist suspect who has escaped from a violent attack the previous evening. Meanwhile Katy, a fun-loving young woman, wakes up with a severe hangover and memory-loss, along with a mysterious man in her bed.