A television reporter and her cameraman are trapped inside a building quarantined by the CDC after the outbreak of a mysterious virus which turns humans into bloodthirsty killers.

The vampire Angel, cursed with a soul, moves to Los Angeles and aids people with supernatural-related problems while questing for his own redemption. A spin-off from Buffy the Vampire Slayer.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.