During a flight from Los Angeles to London, frequent power outages lead to passengers mysteriously disappearing one by one. With the remaining passengers lives on the line, an Air Marshal (Michael Pare) jumps into action while he tries to determine what is going on.

Nicholas Hathaway, a furloughed convict, and his American and Chinese partners hunt a high-level cybercrime network from Chicago to Los Angeles to Hong Kong to Jakarta. As Hathaway closes in, the stakes become personal as he discovers that the attack on a Chinese nuclear power plant was just the beginning.

An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.