Baby Bink couldn't ask for more: he has adoring (if somewhat sickly-sweet) parents, lives in a huge mansion, and he's just about to appear in the social pages of the paper. Unfortunately, not everyone in the world is as nice as Baby Bink's parents—especially the three enterprising kidnappers who pretend to be photographers from the newspaper. Successfully kidnapping Baby Bink, they have a harder time keeping hold of the rascal, who not only keeps one step ahead of them, but seems to be more than a little bit smarter than the three bumbling criminals.

Instead of flying to Florida with his folks, Kevin ends up alone in New York, where he gets a hotel room with his dad's credit card—despite problems from a clerk and meddling bellboy. But when Kevin runs into his old nemeses, the Wet Bandits, he's determined to foil their plans to rob a toy store on Christmas Eve.

A large spider from the jungles of South America is accidentally transported in a crate with a dead body to America where it mates with a local spider. Soon after, the residents of a small California town disappear as the result of spider bites from the deadly spider offspring. It's up to a couple of doctors with the help of an insect exterminator to annihilate these eight legged freaks.