After a tragic accident, six friends reunite for a caving expedition. Their adventure soon goes horribly wrong when a collapse traps them deep underground and they find themselves pursued by bloodthirsty creatures. As their friendships deteriorate, they find themselves in a desperate struggle to survive the creatures and each other.

A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.