A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.

A master jewel thief in 21st century Los Angeles targets the illegal emerald smuggling operations of a highly-connected crime syndicate. During what he believes to be a routine heist, cat burglar Harry Maxwell discovers that his target, notorious criminal Sanchez Boon is also the target of a police raid. In attempting to evade both the law and Boon's well-armed men, Harry meets Pandora Grimes, one of dozens of young women Boon kidnapped to work in his factory. When Boon sets a group of social deviants free and hijacks a space transport ship and its crew, only Harry and Pandora's cunning can save the hundreds of innocent people aboard.