It is the year 2058. Maria Ana, an old Woman lives alone. Her husband Alesandro died years earlier due to a terminal illness. Memory Corp is a company that offers its users the opportunity to see in detail specific moments from their past, allowing them to relive memories via a connection made through neuroscientific technology. Maria Ana goes to Memory Corp every day to meet with Alesandro and relive moments with the love of her life, but one day an error occurs in the system that causes the loss of her entire past, taking Alesandro with it and completely altering her current reality.

Following in the footsteps of the first film, "The Price of the American Dream II" continues the story of Laura Munoz who has grown considerably older and is now a single mother with four children after the death of her husband Chendo. As a result, Laura moves her family from Los Angeles, California to Albuquerque, New Mexico in hopes of gaining a better life for herself and for her children Manny, Alexendra, Daniel, and Carlos. However, life proves to be just as hard in a new state when Manny and Alex begin hanging out with the wrong crowd including the fact that Carlos is now constantly getting in trouble at school and Daniel is even trapped in the middle of it. It seems the price of the American dream has only risen higher since Laura first found it.

Antonio and Teresa are a couple who live in a flat in San Sebastian. Ursula Michelena, an elderly woman over 70 years old, lives on the top floor. Ursula is secretly in love with Antonio, whom he continually spies from one of the windows of her house. One night she sees Antonio and Teresa making love and that fact excites her violently, in such a way that she asks Antonio for a secret appointment and tells her that she is pregnant and that the son she is waiting for is his. Úrsula, according to her version, has become pregnant looking at Antonio and Teresa making love.