In the present, artist Tom Warshaw recalls his traumatic coming of age. As a 13-year-old growing up in New York City in 1973, Tom hangs out with Pappass, a mentally disabled man. With Tom's mother battling depression after the death of her husband, the young boy is left to his own devices. When Tom develops a crush on schoolmate Melissa, Pappass feels abandoned and begins behaving erratically.

Fired from his band and hard up for cash, guitarist and vocalist Dewey Finn finagles his way into a job as a fifth-grade substitute teacher at a private school, where he secretly begins teaching his students the finer points of rock 'n' roll. The school's hard-nosed principal is rightly suspicious of Finn's activities. But Finn's roommate remains in the dark about what he's doing.

Marisa Ventura is a struggling single mom who works at a posh Manhattan hotel and dreams of a better life for her and her young son. One fateful day, hotel guest and senatorial candidate Christopher Marshall meets Marisa and mistakes her for a wealthy socialite. After an enchanting evening together, the two fall madly in love. But when Marisa's true identity is revealed, issues of class and social status threaten to separate them. Can two people from very different worlds overcome their differences and live happily ever after?

The mafia's Paul Vitti is back in prison and will need some serious counseling when he gets out. Naturally, he returns to his analyst Dr. Ben Sobel for help and finds that Sobel needs some serious help himself as he has inherited the family practice, as well as an excess stock of stress.

Isaac Geldhart is a Holocaust survivor who, overcome by grief at the recent death of his wife, seems determined to run his publishing firm into the ground by printing books that have no hope of financial success. His son Aaron, who also works at the company, grows frustrated with Isaac's emotional decline and attempts to take over the firm. The resulting crisis involves Isaac's other two children, his daughter Sarah and his dying son Martin.