As a child, Ali Neuman narrowly escaped being murdered by Inkhata, a militant political party at war with Nelson Mandela's African National Congress. Only he and his mother survived the carnage of those years. But as with many survivors, the psychological scars remain.

Carl Lucas / Frankenstein has won four of his races and needs to win one more to win his freedom. Before his final race, Lucas and his team, car and all, are transferred to another prison where they will compete in a Death Race in the desert. Also, at the same time, Ceaser runs into a marketer who wants to franchise the Death Race program.

The lethal Reaper virus spreads throughout Britain—infecting millions and killing hundreds of thousands. Authorities brutally and successfully quarantine the country but, three decades later, the virus resurfaces in a major city. An elite group of specialists is urgently dispatched into the still-quarantined country to retrieve a cure by any means necessary. Shut off from the rest of the world, the unit must battle through a landscape that has become a waking nightmare.