Cami is a dedicated student of entomology that is researching insects in her sorority house. When her sorority sister Josi sprays insecticide on her bugs, Cami becomes upset. But sooner she learns that the insects had grown bigger and bigger and she and her sisters are under siege by the insects. Further, Josi is the host of the breed of mutant insects that are very hungry.

Michael Jennings is a genius who's hired – and paid handsomely – by high-tech firms to work on highly sensitive projects, after which his short-term memory is erased so he's incapable of breaching security. But at the end of a three-year job, he's told he isn't getting a paycheck and instead receives a mysterious envelope. In it are clues he must piece together to find out why he wasn't paid – and why he's now in hot water.

When a young man agrees to housesit for his boss, he thinks it'll be the perfect opportunity to get close to the woman he desperately has a crush on – his boss's daughter. But he doesn't plan on the long line of other houseguests that try to keep him from his mission. And he also has to deal with the daughter's older brother, who's on the run from local drug dealers.

Can you tell the difference between fact and fiction? Several stories of strange, mysterious and incredible occurrences are chronicled during each episode. It is up to the viewer to decide which stories actually happened and which were completely fabricated by the show’s writers. The answer is revealed by Jonathan Frakes at the conclusion of each episode.