Ciao Darwin is a variety game show format from Italy sold under licence to several countries, including Romania, Hungary, Poland, Serbia, Canada, USA, China and Greece. There are two competing teams of about 50 people each, usually made up of people who fit certain opposing stereotypes. In each game two members of the audience are selected at random, one from each team, indicated by a light in front of them which remains illuminated when all the other team members' lights have gone off. The games involve contestants competing in acts of bravery, style and talent, some of which are designed to humiliate the contestants, especially an assault course which was introduced with the Italian version in 2010, and the Finale which is a water tank game.

Bernardo is dumped by his girlfriend, his career as a rock music critic is beginning to decline and stars to see a psychologist but in the meantime he meets the problematic and shy Camilla, who disrupts his life.

June 27, 1980: a DC–9 flying over the Tyrrhenian Sea breaks up mid-air and crashes near the Italian island of Ustica, killing all 81 people on board. The official version blames the "structural failure" of the plane, but a young journalist smells a cover-up and starts fighting to break free the truth from the 'invisible wall' of lies built by politicians and air force higher-ups.

A young country girl comes to town and works in a brothel in order to help her fiance get the money to start his own business. "Paprika" is the name given to her by the madam.

Two silent movie actors escape from their film. Forced to find a way to survive in the real world, they will only cause troubles to the people they will meet along the way.

Fresh out prison, Tiberio reconnects with his old partners in crime, Michele Ferribote and Peppe the Panther, only to realise that a lot has changed--including crime--after twenty years. Can he cope with this new reality?