Don Matteo is a thoroughly ordinary Catholic priest with an extraordinary ability to read people and solve crimes. He’s a parish priest who never met an unjustly accused person he didn’t want to help.

Aldo and Vittorio are two men suffering from disabilities. One is blind, the other is forced to a wheelchair. Vittorio one day by chance meets Aldo in the hospice and invites him to take a pleasure trip to Sanremo in Liguria. In fact Vittorio, though blind, is a cheat who’s in trouble.

Renzo falls in love with feminist Margherita, too emancipated for him: they start a troubled relationship until he kidnaps her, forcing her to be an housewife devoted to her husband.

Police commissioner Lo Gatto is in charge of the local Italian police station within Vatican State. During an investigation, following the murder of a Vatican priest, he decides to question the Pope! For this reason Lo Gatto is sent to a Sicilian remote island Favignana. There is very little for the commissioner to do on the quiet island, so Lo Gatto decides to investigate the vanishing of a tourist which quickly becomes a very complicated affair.