After receiving a heart transplant, a mundane professor becomes entangled in a grieving mother's plot to avenge her son's death.

Tonino Esposito is the son of the fearsome Camorra boss of Rione Sanità, Naples. Unlike him, however, Tonino is clumsy and utterly innocuous—a good person at heart—and so when his father dies he's passed over in matters of succession. His pride wounded, he doesn't not resign himself and tries to be his own boss, only managing to make a fool of himself. When he discovers that his daughter is dating to the son of the judge who's investigating the boss of Rione Sanità, Tonino sees the opportunity to prove himself in front of his family and all of Naples.

When Debora's ex-husband, a popular neomelodic singer, loses his life in a stage dive, she worries that her 11-year-old son Ciro may be showing symptoms of depression. Taken to a child psychologist, shy Tommaso, Ciro eventually confesses to him that it's not his father's death that has got him down, it's love for his classmate, the cute Ludovica. The two make a deal: Tommaso will help Ciro to win the affections of Ludovica, while Ciro will give Tommaso a hand at having a chance with his mother.

Fired from his HR job in the big city, Fulvio returns home and sees a leaky pipe in his brother's church as the way to save the crumbling town.