On the quiet campus of the remotely-located SouthWestern University, something strange is happening. All of the dogs in the area, once loyal, gentle pets, are now banding together in wild packs and hunting down their former masters. Could the strange transformation have anything to do with the secret government experiments being conducted in the school's physics laboratory? More importantly, can the dogs be stopped before it's too late?

A young couple inherits an old mansion inhabited by small demon-like creatures who are determined to make the wife one of their own.