In 1972, an ambitious female computer programmer must maneuver the minefield of a man's world in order to make an unexpected change for the women in her office.

Eve has married the man of her dreams but when they return to live in the house willed to him by his first wife who died under horrific circumstances, it becomes a waking nightmare as Eve falls into a spiral of suspicion and madness.

William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

Obstetrician/gynecologist Mindy Lahiri tries to balance her personal and professional life, surrounded by quirky co-workers in a small medical practice in New York City.

After her son Kevin commits a horrific act, troubled mother Eva reflects on her complicated relationship with her disturbed son as he grew from a toddler into a teenager.