In this futuristic science fiction thriller, government security agent Jerry Hipple has been unsuccessfully tracking the city's most infamous criminal - The Red Harvest Killer. When two nomadic lovers, Katia and Gladys enter the city the death count rises and are being credited as Red Harvest killings. Obsessive compulsive Adrian, the actual Red Harvest Killer, becomes furious that the sexy serial killing duo are grabbing media attention under his alias. Not only does Adrian attempt to reclaim his rightful reputation but he also decides to cleverly aid his detective counterpart through the case. All the while, killers and victims alike are unaware the world is about to reach an abrupt catastrophic ending.

In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly, and patient Jeffrey Goines, the son of a famous virus expert, who may hold the key to the mysterious rogue group, the Army of the 12 Monkeys, thought to be responsible for unleashing the killer disease.