Twenty years old and from Leicester, Nina moves to North London in 1982, to care for the two young boys of a working single mother, George, the editor of a London literary review.

Sam was born with an extremely rare genetic disorder called Familial Dysautonomia. When born, he had 50 per cent chance of making it to his fifth birthday. Now, at the age of 39 we follow this exceptional person as he pursues his joint goals of getting his acting career back on track and finding love.